Frequently Asked Questions


How is INVEGA TRINZA® different from my current schizophrenia medication?

INVEGA TRINZA® is the only treatment for schizophrenia that helps provide symptom control for 3 months in a single dose*. This means that unlike other daily pills or injections, you only have to take it four times a year. Everyone's needs are different. Talk to your doctor to see if this medication fits your needs and treatment goals.

*After being adequately treated with INVEGA SUSTENNA® (paliperidone palmitate), the once-monthly version of the active medication in INVEGA TRINZA®, for at least four months.

How do I receive INVEGA TRINZA®?

Your doctor may give you an oral test dose to determine if you are allergic to any of the ingredients in INVEGA TRINZA®. Then you will receive your first starting dose of INVEGA SUSTENNA®, followed by a second starting dose one week later. Starting doses are not necessary if you are currently taking INVEGA SUSTENNA®.

After being adequately treated with INVEGA SUSTENNA® for at least four months, you and your healthcare professional may have a discussion about transitioning to INVEGA TRINZA®. Your doctor will give you an injection of INVEGA TRINZA® once every 3 months. INVEGA TRINZA® is gradually released in your body. One dose, given by injection from a healthcare professional, is proven to help control schizophrenia symptoms for 3 months. So it only has to be taken four times a year.

How is INVEGA TRINZA® gradually released in my body?

Each dose of INVEGA TRINZA® is designed to gradually release in your body to help control your schizophrenia symptoms over 3 full months. When given once every 3 months by a healthcare professional as part of your overall treatment plan, INVEGA TRINZA® can help control symptoms of schizophrenia—and delay time to relapse. So you can focus on moving forward toward your treatment goals.

Do people usually have any kind of reaction where they receive their injection?

People may feel some pain or discomfort after receiving an injection of INVEGA TRINZA®. During a clinical trial, just 3% of those treated with INVEGA TRINZA® experienced some sort of reaction at the injection site vs. 0% with placebo.

What if I miss a dose of INVEGA TRINZA®?

It is very important to keep all of your appointments and get your injections on time. If you miss your appointment, call your doctor or Treatment Team as soon as you can. Your doctor or Treatment Team will decide what you should do next and work with you to schedule an appointment as soon as possible. If you stop coming for your injections, your symptoms may return.

You should not stop receiving injections of this medicine unless you have discussed this with your doctor. If you are still experiencing symptoms or side effects, be sure to let your healthcare professional know, as they may be able to adjust your dosage to ensure the medication is safe and effective for you.



What if I need help affording my medication?

Finding the right medication for you is an important part of your treatment journey. But, it also has to be affordable. There are financial support options available that can help make it more affordable—whether or not you have insurance.

Since INVEGA TRINZA® is a 3-month dose, and INVEGA SUSTENNA® (paliperidone palmitate) is a one-month dose, is the 3-month dose much more expensive?

Be sure to check with your insurance provider for the exact cost, but the cost of your medication should remain consistent. Even though INVEGA TRINZA® is medication for 3 months at a time, to most patients, the cost per month is the same.

How will I remember when it’s time to take my next dose?

Your healthcare provider will tell you how much INVEGA TRINZA® you will receive and when you will receive it. If you’re receiving INVEGA SUSTENNA® or INVEGA TRINZA®, you and your healthcare professional can discuss options for programs or providers that may be able to provide you with reminders for your injection appointments, depending on availability in your area.



What are the possible side effects?

The most common side effects of INVEGA TRINZA® include injection site reactions, weight gain, headache, upper respiratory tract infections, feeling restlessness or difficulty sitting still, slow movements, tremors, stiffness and shuffling walk.

The most common side effects of INVEGA SUSTENNA® include injection site reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or needing to be constantly moving; abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes.

Please see Important Safety Information for additional information regarding side effects.

What should I avoid while receiving INVEGA TRINZA®?

INVEGA TRINZA® may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how INVEGA TRINZA® affects you. Avoid becoming overheated or dehydrated.